Generalized Anxiety Disorder (2023)

Continuing Education Activity

Generalized anxiety disorder is a mental health disorder that produces fear, worry, and a constant feeling of being overwhelmed. It is characterized by excessive, persistent, and unrealistic worry about everyday things. This activity illustrates the evaluation and management of generalized anxiety disorder and explains the interprofessional team's role in managing patients with this condition.

Objectives:

• Summarize the etiology of generalized anxiety disorder.

• Describe the use of the Generalized Anxiety Disorder 7-Item Questionnaire in the evaluation of generalized anxiety disorder.

• Identify the use of cognitive-behavioral therapy in the management of patients with a generalized anxiety disorder.

• Outline the importance of collaboration and communication among the interprofessional team to enhance care delivery for patients affected by a generalized anxiety disorder.

Access free multiple choice questions on this topic.

Introduction

Generalized anxiety disorder is one of the most common mental disorders. Up to 20% of adults are affected by anxiety disorders each year. Generalized anxiety disorderproduces fear, worry, and a constant feeling of being overwhelmed. Generalized anxiety disorder is characterized by persistent, excessive, and unrealistic worry about everyday things. This worry could be multifocal such as finance, family, health, and the future. It is excessive, difficult to control, and is often accompanied by many non-specific psychological and physical symptoms. Excessive worry is the central feature of generalized anxiety disorder.[1][2][3]

Diagnostic criteria in the Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-5) includethe following:

• Excessive anxiety and worry for at least six months

• Difficulty controlling the worrying.

• The anxiety is associated with three or more of the below symptoms for at least 6 months:

1. Restlessness, feeling keyed up or on edge

2. Being easily fatigued

3. Difficulty in concentrating or mind going blank, irritability

4. Muscle tension

5. Sleep disturbance

6. Irritability

• The anxiety results in significant distress or impairment in social and occupational areas

• The anxiety is not attributable to any physical cause

Etiology

The etiology may include:

• Stress

• A physical condition such as diabetes or other comorbidities such as depression

• Genetic, first-degree relatives withgeneralized anxiety disorder(25%)

• Environmental factors, such as child abuse

• Substance use disorder

Epidemiology

Childhood anxiety occurs in about 1 in 4children at some timebetween the ages of 13 and 18 years. The median age at onset is 11 years. However, the lifetime prevalence of a severe anxiety disorder in children ages 13 to 18is approximately 6%. General prevalence in children younger than 18 years is between 5.7% and 12.8%. The prevalence is approximately twice as high among women as among men.[4][5][6]

The American Psychiatric Association first introduced the diagnosis of generalized anxiety disorder two decades ago in the DSM-III. Before that time,generalized anxiety disorderwas conceptualized as one of the two core components of anxiety neurosis, the other being panic. A recognition thatgeneralized anxiety disorderand panic, although often occurring together, are sufficiently distinct to be considered independent disorders led to their separation in the DSM-III.

The DSM-III definition ofgeneralized anxiety disorderrequired uncontrollable and diffuse (i.e., not focused on a single major life problem) anxiety or worry that is excessive or unrealistic relative to objective life circumstances and persists for one month or longer. Several related psychophysiological symptoms were alsorequired for a diagnosis ofgeneralized anxiety disorder. Early clinical studies evaluating DSM-III, according to this definition, found that the disorder seldom occurred in the absence of another comorbid anxiety or mood disorder. Comorbidity ofgeneralized anxiety disorderand major depression was especially strong and led somecommentators to suggest thatgeneralized anxiety disordermight better be conceptualized as a prodrome, residual, or severity marker than as an independent disorder. The rate of comorbidity ofgeneralized anxiety disorderwith other disorders decreases as the duration ofgeneralized anxiety disorderincreases. Based on this finding, the DSM-III-R committee ongeneralized anxiety disorderrecommended that the duration required for the disorder be increased to six months. This change was implemented in the final version of the DSM-III-R. Additional changes in the definition of excessive worry and the required number of associated psychophysiological symptoms were made in the DSM-IV.

These changes in diagnostic criteria led to delays in cumulating data on the epidemiology ofgeneralized anxiety disorder. Nonetheless, such data became available over the past decade. As described in more detail later, this new data challenged the view thatgeneralized anxiety disordershould be conceptualized as a prodrome, residual, or severity marker of other disorders. Instead, itsuggests thatgeneralized anxiety disorderis a common disorder that, although often comorbid with other mental disorders, does not have a higher comorbidity rate than those found in most other anxiety or mood disorders. The new data also challenged the validity of the threshold decisions embodied in the DSM-5.

Pathophysiology

The exact mechanism is notentirely known. Anxiety can be a normal phenomenon in children. Stranger anxiety begins at seven to nine months of life. Noradrenergic, serotonergic, and other neurotransmitter systems appear to play a role in the body's response to stress. The serotonin system and the noradrenergic systems are common pathways involved in anxiety. Many believe thatlow serotonin system activity and elevated noradrenergic system activity are responsible for its development. Therefore, it is selective serotonin reuptake inhibitors (SSRI) and serotonin-norepinephrine reuptake inhibitors (SNRI) that are the first-line agent for its treatment.

History and Physical

Patients with anxiety can pose a diagnostic challenge, as somatic symptoms are more common than psychological symptoms. Most patients present with vague or nonspecific somatic complaints, including, but not limited to,shortness of breath, palpitations, fatigability, headache, dizziness, and restlessness. Patients may also describe psychologic symptoms such as excessive, nonspecific anxiety and worry, emotional lability,difficulty concentrating, and insomnia.

Factors commonly associated with generalized anxiety include:

• Female gender

• Unmarried

• Poor health

• Low education

• Presence of stressors

The median age of presentation is 30 years.

Many scales have been developed to assess the severity and diagnosis. The GAD-7 has been validated as a diagnostic tool and severity assessment scale.

Evaluation

Initial assessment begins by addressing behavioral or somatic symptoms. Evaluate for psychosocial stress, psychosocial difficulties, and developmental issues. Review past medical history,includingtrauma, psychiatric conditions, and substance abuse.[7]

The following evaluation may be obtained to exclude organic causes:

• Thyroid function tests

• Blood glucose level

• Echocardiography

• Toxicology screen

The Generalized Anxiety Disorder 7-Item (GAD-7) Questionnaire is a screening tool that can also be used to monitor patients withgeneralized anxiety disorder.

Treatment / Management

The two main treatments for generalized anxiety disorder are cognitive behavioral therapy and medications. Patients may benefit most from a combination of the two. It may take sometrial and error to discover which treatments work best.[8][9][10]

Cognitive Behavioral Therapy

This includes psychoeducation, changing maladaptive thought patterns, and gradual exposure to anxiety-provoking situations.

Pharmacotherapy

Patients who do not respond to cognitive behavioral therapy may be treated with medications. Some patients with severe symptoms are treated with both initially. Several types of medications are used to treat generalized anxiety disorder.

Antidepressants

Selective serotonin reuptake inhibitor (SSRI) and serotonin-norepinephrine reuptake inhibitor (SNRI) classes are the first-line agents with a response rate of 30% to 50%. This class of drugs includes escitalopram (Lexapro), duloxetine (Cymbalta), venlafaxine (Effexor XR), and paroxetine (Paxil, Pexeva). In a study, 81% of children with anxiety disorders who received combined sertraline hydrochloride and CBT responded to the treatment.

Antipsychotics may also help some patients, especially those with associated behavior problems.

Benzodiazepines

Examples are diazepam and clonazepam, which are long-acting agents. These agents are used when an immediate reduction of symptoms is desired, or a short-term treatment is needed. Generally, cooperative and compliant patients who are aware that their symptoms have a psychological basis are more likely to respond to benzodiazepines. Since there is a concern for misuse and dependence, patients with a history of alcoholism or drug abuse are not appropriate candidates for this treatment.

Buspirone

Buspirone is a non-benzodiazepine that does not cause dependency. It is also less sedating than benzodiazepines, and tolerance does not occur at therapeutic doses. This agent has a therapeutic lag in the efficacy of two to threeweeks, limiting its use.

All medications should be titrated slowly and continued for at least 4 weeks to determine if they work. Once symptoms are under control, the medications need to be used for at least 12 months before gradually tapering them. Every medication has adverse effects like weight gain, hyperlipidemia, and diabetes; thus, the patients need to be monitored.

Psychotherapy is used in addition to medications; this combination has proven to be effective.

The education of the patient is vital as it can help ease anxiety. The triggers for anxiety should be managed by avoiding caffeine, alcohol, nicotine, and stress) and improving sleep.

Many complementary and alternative remedies are available, but the evidence to support their efficacy is lacking. Further, some agents like Kava may injure the liver. Others, like St John's wort and hydroxytryptophan, may interact with SSRIs and induce serotonin syndrome.

Differential Diagnosis

• Hyperthyroidism

• Pheochromocytoma

• Chronic obstructive pulmonary disease

• Transient ischemic attack

• Epilepsy

• Bipolar disorder

• Use of caffeine, decongestants, and albuterol

Prognosis

The prognosis for patients with generalized anxiety disorder is guarded. Many patients are not compliant with medications because of cost and adverse effects. Relapses are common, and patients often search for physicians who comply with their needs. Because of the lack of conventional medicine to cure the disorder, many opt for alternative therapies without much success. Overall, the quality of life of these patients is poor.

Complications

Complications of generalizedanxiety disorder can also lead to, or worsen, other mental and physical conditions[11]:

• Depression (often presents concomitantly with an anxiety disorder)

• Insomnia

• Drug or alcohol use disorder

• Gastrointestinal problems

• Social isolation

• Issues functioning at work/school

• Impaired quality of life

• Suicide potential

Deterrence and Patient Education

Patients with anxiety disorders need to understand the importance of medication compliance (anxiolytics, antidepressants, sleepinducers), working with any cognitive therapy prescribed, and thebenefit of stopping the use of caffeine or other stimulants.

Pearls and Other Issues

Consider further evaluation for anxiety disorder if an adult is excessively anxious or an infant or child is excessively clingy and difficult to console during the pediatric visit. Many medical conditions may mimic anxiety disorders. One should distinguish between anxiety and illness and should evaluate for organic diseases before making this diagnosis.

Enhancing Healthcare Team Outcomes

Anxiety disorders are verycommon and can have a diverse presentation of signs and symptoms. The condition has very high morbidity and mortality and is best managed by an interprofessional team that includes a mental health nurse, pharmacist, psychologist, psychiatrist, and primary care provider. Many patients have moderate to severe symptoms, which lead to poor quality of life. Most have no idea that the condition can be treated. Thus, the key to improving outcomes is patient education. The nurse practitioner, pharmacist, and primary care provider should urge the patient to stop tobacco, alcohol, and caffeinated beverages. Also, relief of stress is vital, and thus a referral for cognitive behavior therapy may help.

Many drugs can be used to treat anxiety, but they all have side effects, which is a common reason for non-compliance. The pharmacist should emphasize the benefits of these medications and urge compliance to improve the symptoms. At the same time, the primary care provider should monitor for hyperlipidemia, diabetes, and weight gain due to the medications.

Overall, anxiety disorders are underdiagnosed and undertreated. When left untreated, anxiety disorders often lead to severe depression and abuse of drugs and alcohol. Additionally, there is a high rate of suicide among these patients. Many patients with chronic anxiety have a poor quality of life. The education of both the patient and family by the pharmacist, nurse, and provider as a team is important to reduce the high morbidity and addiction problems with treatment medications. Family members should help ensure medication compliance and provide a supportive environment. Unfortunately, despite optimal treatment, relapse rates are high.[12][13][14][Level5]

Review Questions

• Access free multiple choice questions on this topic.

• Comment on this article.

References

1.

Leonard K, Abramovitch A. Cognitive functions in young adults with generalized anxiety disorder. Eur Psychiatry. 2019 Feb;56:1-7. [PubMed: 30458333]

2.

Roomruangwong C, Simeonova DS, Stoyanov DS, Anderson G, Carvalho A, Maes M. Common Environmental Factors May Underpin the Comorbidity Between Generalized Anxiety Disorder and Mood Disorders Via Activated Nitro-oxidative Pathways. Curr Top Med Chem. 2018;18(19):1621-1640. [PubMed: 30430941]

3.

Grenier S, Desjardins F, Raymond B, Payette MC, Rioux MÈ, Landreville P, Gosselin P, Richer MJ, Gunther B, Fournel M, Vasiliadis HM. Six-month prevalence and correlates of generalized anxiety disorder among primary care patients aged 70years and above: Results from the ESA-services study. Int J Geriatr Psychiatry. 2019 Feb;34(2):315-323. [PubMed: 30418683]

4.

Silva MT, Caicedo Roa M, Martins SS, da Silva ATC, Galvao TF. Generalized anxiety disorder and associated factors in adults in the Amazon, Brazil: A population-based study. J Affect Disord. 2018 Aug 15;236:180-186. [PubMed: 29747135]

5.

Scheeringa MS, Burns LC. Generalized Anxiety Disorder in Very Young Children: First Case Reports on Stability and Developmental Considerations. Case Rep Psychiatry. 2018;2018:7093178. [PMC free article: PMC6174746] [PubMed: 30345136]

6.

Ströhle A, Gensichen J, Domschke K. The Diagnosis and Treatment of Anxiety Disorders. Dtsch Arztebl Int. 2018 Sep 14;155(37):611-620. [PMC free article: PMC6206399] [PubMed: 30282583]

7.

Rosellini AJ, Bourgeois ML, Correa J, Tung ES, Goncharenko S, Brown TA. Anxious distress in depressed outpatients: Prevalence, comorbidity, and incremental validity. J Psychiatr Res. 2018 Aug;103:54-60. [PMC free article: PMC8903047] [PubMed: 29778071]

8.

Latas M, Trajković G, Bonevski D, Naumovska A, Vučinić Latas D, Bukumirić Z, Starčević V. Psychiatrists' treatment preferences for generalized anxiety disorder. Hum Psychopharmacol. 2018 Jan;33(1) [PubMed: 29266492]

9.

Driot D, Bismuth M, Maurel A, Soulie-Albouy J, Birebent J, Oustric S, Dupouy J. Management of first depression or generalized anxiety disorder episode in adults in primary care: A systematic metareview. Presse Med. 2017 Dec;46(12 Pt 1):1124-1138. [PubMed: 29150233]

10.

Roberge P, Normand-Lauzière F, Raymond I, Luc M, Tanguay-Bernard MM, Duhoux A, Bocti C, Fournier L. Generalized anxiety disorder in primary care: mental health services use and treatment adequacy. BMC Fam Pract. 2015 Oct 22;16:146. [PMC free article: PMC4618956] [PubMed: 26492867]

11.

Juruena MF, Eror F, Cleare AJ, Young AH. The Role of Early Life Stress in HPA Axis and Anxiety. Adv Exp Med Biol. 2020;1191:141-153. [PubMed: 32002927]

12.

Jordan P, Shedden-Mora MC, Löwe B. Predicting suicidal ideation in primary care: An approach to identify easily assessable key variables. Gen Hosp Psychiatry. 2018 Mar-Apr;51:106-111. [PubMed: 29428582]

13.

Dold M, Bartova L, Souery D, Mendlewicz J, Serretti A, Porcelli S, Zohar J, Montgomery S, Kasper S. Clinical characteristics and treatment outcomes of patients with major depressive disorder and comorbid anxiety disorders - results from a European multicenter study. J Psychiatr Res. 2017 Aug;91:1-13. [PubMed: 28284107]

14.

Cho SJ, Hong JP, Lee JY, Im JS, Na KS, Park JE, Cho MJ. Association between DSM-IV Anxiety Disorders and Suicidal Behaviors in a Community Sample of South Korean Adults. Psychiatry Investig. 2016 Nov;13(6):595-600. [PMC free article: PMC5128346] [PubMed: 27909449]

Disclosure: Sadaf Munir declares no relevant financial relationships with ineligible companies.

Disclosure: Veronica Takov declares no relevant financial relationships with ineligible companies.